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. 2015 Jul 6;65(10):1744–1753. doi: 10.1136/gutjnl-2014-307856

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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Interferon alpha 2a (IFNα-2a) treatment prevents disease progression in mice infected with HCV. HIL mice were treated with IFNα-2a three times a week starting from 1 week post mock-infection or HCV-infection (n=5 mice per group). Livers and sera were harvested at 8 weeks after infection for histology, ELISA and alanine aminotransferase (ALT) measurement. (A) Representative liver stains of H&E to visualise leucocyte infiltration (top row) and stains for Sirius red/Fast green to visualise collagen deposition (bottom row) are shown. (B) Serum levels of human IFNγ were determined by ELISA. (C) Serum levels of human interleukin-6 were determined by ELISA. (D) Serum ALT levels of HIL mice from different treatment groups are represented in the graph. (E) Human epidermal growth factor receptor⁺ cells purified from livers of mock-infected, HCV-infected HIL mice treated with phosphate buffered saline (PBS) or IFNγ-2a (indicated by ^α) at 2 and 5 weeks post-infection (1 and 4 weeks post-IFNγ-2a treatment, respectively) and analysed for HCV RNA by RT-PCR (n=5 mice per group). Data represent mean±SEM.