Table 4.
Area under the curve and slope analysis of cortisol for genetic variants
| Drug | Gene | CHR | SNP | Basepair | Minor allele | N | P value |
|---|---|---|---|---|---|---|---|
| Area under the curve analysis: | |||||||
| Prednisone | IPO13 | 1 | rs6671164 | 44403489 | G | 8 | 0.015 |
| Prednisone | IPO13 | 1 | rs4448553 | 44411589 | A | 9 | 0.007 |
| Prednisone | IPO13 | 1 | rs1990150 | 44414127 | G | 9 | 0.023 |
| Prednisone | IPO13 | 1 | rs2240447 | 44415415 | C | 9 | 0.007 |
| Prednisone | IPO13 | 1 | rs2301993 | 44426025 | C | 9 | 0.007 |
| Prednisone | IPO13 | 1 | rs7412307 | 44433864 | G | 8 | 0.015 |
| Prednisone | IPO13 | 1 | rs2428953 | 44443459 | A | 9 | 0.023 |
| Prednisone | GLCCI1 | 7 | rs37973 | 8007876 | G | 9 | 0.038 |
| Slope analysis: | |||||||
| Hydrocortisone | ABCB1 | 7 | rs1045642 | 87138645 | A | 9 | 0.026 |
| Hydrocortisone | ABCBI | 7 | rs2032582 | 87160618 | A | 9 | 0.026 |
| Hydrocortisone | ABCB1 | 7 | rs1128503 | 87179601 | A | 9 | 0.026 |
Abbreviations: CHR chromosome, SNP single nucleotide polymorphism, IPO13 importin-13, GLCCI1 glucocorticoid-induced transcript 1, ABCB1 ATP-binding cassette sub-family B member 1