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. 2016 Sep 26;17:189. doi: 10.1186/s13059-016-1052-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Microbial functional analysis in obesity. a Microbial PICRUSt-predicted KEGG functions relevant to metabolism in the twin dataset, and their association with the six adiposity measures. The heatmap denotes the direction of association between each microbial PICRUSt-predicted KEGG function and adiposity measures, where blue indicates a negative association, while red indicates a positive association. Bonferroni-significant associations are highlighted (*). b Five KO genes that are differentially abundant between high and low visceral fat individuals in glyoxylate and dicarboxylate metabolism, as tested by a two-sided Welch’s t test. FDR-adjusted P values are reported at the right of the image, and stars indicate Bonferroni-significant associations. Figure was produced using STAMP [45]