Table 3.

Association Between Germline Variants and Clinical Parameters of PTC (n = 1216)

		Sex (males)		Age		T0–T2 vs. T3–T4		N stage		M stage		High risk vs. low-risk patients
SNP	Locus	OR[CI]	p-Value	Slope	p-Value	OR[CI]	p-Value	OR[CI]	p-Value	OR[CI]	p-Value	OR[CI]	p-Value
rs965513	9q22.33	1.05	0.640	−0.01	0.984	1.06	0.536	1.10	0.270	0.86	0.465	1.13	0.256
		[0.87–1.26]		[–1.16 to 1.14]		[0.88–1.29]		[0.93–1.31]		[0.56–1.30]		[0.91–1.41]
rs944289	14q13.3	1.03	0.800	−1.04	0.092	1.05	0.623	0.99	0.942	0.76	0.212	1.00	0.999
		[0.84–1.25]		[–2.26 to 0.17]		[0.86–1.30]		[0.83–1.19]		[0.49–1.17]		[0.80–1.25]
rs116909374	14q13.3	0.88	0.510	0.19	0.880	0.95	0.812	0.61	0.016	1.38	0.421	0.82	0.39
		[0.59–1.32]		[–2.33 to 2.72]		[0.61–1.44]		[0.41–0.90]		[0.57–2.87]		[0.51–1.29]
rs2439302	8p12	1.01	0.946	0.55	0.365	1.07	0.505	1.24	0.016	1.20	0.408	1.10	0.419
		[0.83–1.22]		[–0.64 to 1.73]		[0.88–1.31]		[1.04–1.49]		[0.78–1.87]		[0.88–1.37]
rs966423	2q35	1.01	0.934	−0.32	0.581	0.85	0.114	1.05	0.596	0.75	0.184	0.84	0.126
		[0.84–1.21]		[–1.44 to 0.81]		[0.70–1.04]		[0.88–1.25]		[0.48–1.14]		[0.67–1.05]
CGRS		1.02	0.660	−0.27	0.370	1.01	0.830	1.06	0.176	0.95	0.626	1.01	0.907
		[0.93–1.13]		[–0.86 to 0.32]		[0.92–1.12]		[0.97–1.16]		[0.76–1.17]		[0.90–1.13]
wCGRS		1.03	0.619	−0.18	0.559	1.02	0.748	1.03	0.471	0.98	0.823	1.02	0.758
		[0.93–1.13]		[–0.77 to 0.42]		[0.92–1.12]		[0.95–1.13]		[0.78–1.21]		[0.91–1.14]

The lower half of the table shows Cumulative Genetic Risk Scores (CGRS) and weighted CGRS for all five variants for a given clinical parameter. Low-risk patients = T1a, N0, M0. High-risk patients = T3, T4, or M1.