Table 4.

Association Between Germline Variants and Clinical Parameters of PTC (n = 1216)

		Tumor diameter		Multifocality		Lymphovascular invasion		Capsular invasion		Extrathyroidal expansion		MACIS score
SNP	Locus	Slope	p-Value	OR[CI]	p-Value	OR[CI]	p-Value	OR[CI]	p-Value	OR[CI]	p-Value	Slope	p-Value
rs965513	9q22.33	0.14	0.025	1.00	0.972	1.23	0.066	1.02	0.845	1.29	0.045	0.03	0.542
		[0.02–0.27]		[0.85–1.18]		[0.99–1.53]		[0.81–1.29]		[1.01–1.67]		[−0.06 to 0.12]
rs944289	14q13.3	−0.01	0.900	1.07	0.462	0.98	0.843	1.04	0.734	0.87	0.28	−0.07	0.165
		[−0.14 to 0.12]		[0.90–1.27]		[0.78–1.23]		[0.82–1.34]		[0.67–1.12]		[−0.17 to 0.03]
rs116909374	14q13.3	−0.06	0.660	1.39	0.073	0.61	0.081	1.41	0.139	1.19	0.528	0.03	0.767
		[−0.33 to 0.21]		[0.97–2.00]		[0.34–1.03]		[0.88–2.19]		[0.69–2.01]		[−0.17 to 0.23]
rs2439302	8p12	0	0.960	1.24	0.012	1.11	0.365	1.17	0.197	1.07	0.601	0.03	0.567
		[−0.13 to 0.12]		[1.05–1.48]		[0.88–1.40]		[0.92–1.5]		[0.83–1.38]		[−0.07 to 0.12]
rs966423	2q35	−0.09	0.178	1.12	0.188	0.92	0.487	0.91	0.403	0.97	0.825	−0.05	0.288
		[−0.21 to 0.04]		[0.95–1.32]		[0.74–1.15]		[0.72–1.14]		[0.75–1.25]		[−0.14 to 0.04]
CGRS		0.03	0.396	1.12	0.008	1.06	0.335	1.06	0.314	1.08	0.249	0	0.925
		[−0.04 to 0.09]		[1.03–1.22]		[0.95–1.18]		[0.94–1.20]		[0.95–1.23]		[−0.05 to 0.05]
wCGRS		0.06	0.090	1.09	0.045	1.07	0.222	1.07	0.265	1.13	0.075	0.01	0.636
		[−0.01 to 0.12]		[1.00–1.19]		[0.96–1.20]		[0.95–1.21]		[0.99–1.28]		[−0.04 to 0.06]

The lower half of the table shows CGRS and wCGRS for all five variants for a given clinical parameter.