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. 2016 Sep 1;22(6):499–509. doi: 10.1089/mdr.2016.0128

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© Regina Kilian, et al., 2016; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 1. — (A, B) EMBOSS stretcher pairwise sequence alignment of VnlRS_Ab and VanRS_Sc. (A) EMBOSS stretcher pairwise sequence alignment of VnlS_Ab and VanS_Sc. Transmembrane domains are indicated in blue. The extracytosolic domain is highlighted by a red box. (B) EMBOSS stretcher pairwise sequence alignment of VnlR_Ab and VanR_Sc. The site of aspartate phosphorylation is indicated by red and that of the proposed autophosphorylation by green arrow. (C) Organization of the resistance genes in Streptomyces coelicolor compared with that of Amycolatopsis balhimycina. “-” for a mismatch or a gap; “.” for any small positive score; “:” for a similarity, which scores more than 1.0; and “I” for an identity where both sequences have the same residue.