Table 4.

Cognitive Measures in the Low-Normal TSH and High-Normal TSH Groups

	Test	Low-normal TSH mean ± SEM	High-normal TSH mean ± SEM	p-Value
Declarative memory	Paragraph Recall Test
	Immediate	12.6 ± 0.3	12.8 ± 0.5	0.41
	30 min delay	11.1 ± 0.4	11.3 ± 0.6	0.45
Executive function	Letter Cancellation Test
	Time (sec)	100 ± 2	106 ± 3	0.15
	% with no errors	20%	19%	0.91
	Trail Making Test
	Time (sec)	24.2 ± 0.7	24.6 ± 1.3	0.54
	ABC time (sec)	61.8 ± 2.5	60.0 ± 2.6	0.48
	% With errors	11%	15%	0.47
	% With ABC errors	32%	28%	0.53
	Iowa Gambling Task
	Net-1	−4.1 ± 0.9	−1.3 ± 1.4	0.02
	Net-2	5.8 ± 0.9	5.3 ± 1.3	0.70
	Net-3	7.5 ± 1.0	7.7 ± 1.5	0.99
	Net-4	8.3 ± 1.1	5.3 ± 1.6	0.01
	Net-5	7.9 ± 1.2	5.3 ± 1.5	0.04
Executive function (working memory)	N-Back
	No. correct on target
	1-Backa	74%	81%	0.30
	2-Backa	42%	43%	0.92
	3-Back	10.9 ± 0.3	10.4 ± 0.3	0.24
	N-Back
	No. incorrect/nontarget
	1-Backa	28%	13%	0.06
	2-Backa	33%	30%	0.78
	3-Back	3.5 ± 0.2	3.8 ± 0.3	0.77
	Subject Ordered Pointing
	No. of errors
	6	0.6 ± 0.05	0.5 ± 0.1	0.79
	8	1.1 ± 0.1	1.1 ± 0.1	0.87
	10	1.3 ± 0.1	1.5 ± 0.1	0.29
	12	1.7 ± 0.1	1.7 ± 0.2	0.60
Motor learning	Pursuit Rotor Trial
	Time on target (sec)
	1	34.0 ± 1.3	34.4 ± 1.6	0.93
	2	36.4 ± 1.3	37.3 ± 1.5	0.60
	3	37.5 ± 1.4	37.4 ± 1.6	0.88
	4	38.7 ± 1.4	38.6 ± 1.6	0.92
	Motor Sequence Learning Test
	Total movement time (sec)	1123 ± 40	1073 ± 34	0.39

Individual tests are grouped by cognitive subdomains (first column). p-Values for continuous outcomes were adjusted for age, years of education, WAIS-R, BMI, estrogen status, LT4 time, LT4 dose time, and LT4 dose (μg/kg).

Significant differences between the two groups are shown in bold with corresponding p-values.

^aThese values were calculated as proportion of subjects for which each measure was ≥15 (for correct on target) or >0 (for incorrect/nontarget), since there were floor effects. The N-Back p-values for comparing groups do not include three-back, since this variable was not calculated as a proportion.

ABC, Trail Making Test Part B.