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. 2016 Oct;57(10):1906–1916. doi: 10.1194/jlr.P069096

TABLE 4.

Epoxygenase pathway-derived lipid mediators from ω-6 and ω-3 PUFAs in human amniotic fluid in TLB with or without clinical chorioamnionitis

Lipid TLB TCC-noMIAC TCC-MIAC P (TLB vs. TCC-noMIAC) P (TLB vs. TCC-MIAC) P (TCC-noMIAC vs. TCC-MIAC)
9(10)-EpOME 217.2 (172.2–384.9) [35] 113.0 (76.2–166.1) [12] 239.8 (157.4–370.2) [12] 1.20 × 10−4 0.97 0.03
12(13)-EpOME 150.2 (106.4–212.7) [35] 59.9 (51.5–107.3) [12] 116.7 (79.5–212.7) [12] 1.06 × 10−4 0.28 0.16
8(9)-EpETrE 45.7 (28.9–59.9) [35] 14.4 (10.2–21.5) [12] 33.2 (25.2–39.7) [12] 4.97 × 10−7 0.21 0.02
11(12)-EpETrE 200.2 (166.1–307.6) [35] 67.4 (52.1–113.1) [12] 177.8 (129.3–210.0) [12] 6.77 × 10−6 0.24 0.01
14(15)-EpETrE 109.6 (83.7–162.9) [35] 45.1 (23.2–67.3) [12] 80.7 (71.8–115.6) [12] 2.86 × 10−6 0.10 0.02
8(9)-EpETE (ω-3) 2.94 (1.83–3.86) [33] 0.02 (0.02–0.02) [1] 0.02 (0.02–0.02) [2] 1.26 × 10−6 5.33 × 10−6 NA
11(12)-EpETE (ω-3) 14.6 (11.1–19.4) [35] 1.94 (1.42–2.96) [10] 3.45 (2.79–6.00) [11] 6.87 × 10−7 7.70 × 10−8 0.07
17(18)-EpETE (ω-3) 5.94 (3.92–8.80) [35] 0.02 (0.02–0.93) [5] 1.62 (0.51–2.02) [9] 5.81 × 10−7 7.55 × 10−6 0.04
16(17)-EpDPE (ω-3) 9.62 (7.39–14.5) [35] 3.00 (2.32–3.84) [11] 5.21 (2.76–7.58) [12] 6.01 × 10−6 3.55 × 10−3 0.05
19(20)-EpDPE (ω-3) 13.4 (8.63–18.9) [35] 3.02 (2.17–4.12) [12] 6.46 (3.54–6.89) [12] 1.06 × 10−6 1.55 × 10−4 0.02

EpDPE, epoxy docosapentaenoic acid; EpETE, epoxy eicosatetraenoic acid; EpETrE, epoxy eicosatrienoic acid; EpOME, epoxy octadecenoic acid. All concentrations are in nM. Values in parentheses are interquartile ranges of analyte concentrations in nM, and those in brackets are number of samples with detectable levels of the corresponding lipid mediators. All P values are derived from Wilcoxon tests. P values <0.05 were italicized.