Table 1.
Effect of perampanel on cognitive function assessed by CDR System Global Cognition Score in study 235 – full analysis (Meador et al. 2016)
| Parameter | LS mean change (SE) | Difference in LS means (95% CI) | P‐value | |
|---|---|---|---|---|
| Placebo (n = 44) | Perampanel (n = 79) | Perampanel versus placebo | ||
| CDR System Global Cognition Score | 1.6 (1.3) | −0.6 (1.0) | −2.2 (−5.2 to 0.8) | 0.145 |
| Power of attention | −2.7 (3.0) | −6.9 (2.3) | −4.2 (−11.0 to 2.6) | 0.219 |
| Quality of working memory | 2.0 (1.5) | 1.1 (1.2) | −1.0 (−4.4 to 2.5) | 0.579 |
| Continuity of attention | 1.6 (1.2) | −1.7 (0.9) | −3.3 (−6.0 to −0.7) | 0.013 |
| Quality of episodic memory | −1.2 (1.5) | 3.0 (1.1) | 4.2 (0.9 to 7.5) | 0.012 |
| Speed of memory | 7.0 (2.7) | 0.3 (2.1) | −6.6 (−12.7 to −0.6) | 0.032 |
SE, standard error; CI, confidence interval; LS, least squares.
Statistical significance – (P < 0.05).