Table 1.
(A) Anticipatory fear processing in anticipation of the presentation of spider pictures: ASL presymptom provocation task Session 1 versus ASL presymptom provocation task Session 2. (B) Fear post event processing after the presentation of spider pictures: ASL postsymptom provocation task Session 1 versus ASL postsymptom provocation task Session 2. The first three columns describe the clusters resulting from the t‐contrast comparing mean CBF images. The last three columns show the quantified CBF values and the result of the T‐test comparing the mean CBF values
| Region | Cluster size | Coordinates | T peak level | CBF pre [mL/100 g/min] | CBF post [mL/100 g/min] | T‐test pre versus post (gCBF corrected) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| x | y | z | T | P | d | |||||
| (A) | ||||||||||
| Thalamus ventral anterior nucleus | 71 | −2 | −16 | 16 | 9.61 | 61.3 ± 11.9 | 44.0 ± 8.2 | 3.88 | 0.006 | 1.47 |
| Parahippocampal left | 45 | −22 | −26 | −12 | 9.06 | 72.1 ± 7.2 | 50.2 ± 11.5 | 5.69 | 0.001 | 1.60 |
| Parahippocampal right | 11 | 20 | −16 | −12 | 5.94 | 64.3 ± 9.2 | 47.0 ± 11.7 | 3.01 | 0.020 | 1.08 |
| Superior frontal gyrus left | 13 | −14 | 22 | 54 | 6.18 | 64.7 ± 8.3 | 49.8 ± 6.8 | 2.13 | 0.071 | 1.06 |
| BA7 left | 56 | −42 | −72 | 44 | 10.59 | 61.4 ± 6.9 | 50.9 ± 6.1 | 1.75 | 0.123 | 1.01 |
| BA8 right | 10 | 26 | 22 | 54 | 6.33 | 65.4 ± 9.2 | 53.1 ± 4.7 | 3.8 | 0.007 | 1.64 |
| BA24/vACC right | a) 11 | 14 | 14 | 34 | 6.99 | |||||
| b) 21 | 12 | 6 | 42 | 6.65 | 46.6 ± 10.0 | 34.7 ± 8.2 | 2.8 | 0.026 | 0.81 | |
| BA39 left | a) 11 | −44 | −62 | 22 | 5.82 | |||||
| b) 15 | −54 | −66 | 22 | 5.3 | 72.7 ± 11.1 | 61.6 ± 11.1 | 2.17 | 0.067 | 0.38 | |
| BA40 right | 10 | 46 | −56 | 32 | 5.43 | 74.1 ± 7.5 | 60.5 ± 6.3 | 2.2 | 0.064 | 0.95 |
| (B) | ||||||||||
| Insula right | a) 315 | 42 | −6 | 12 | 11.15 | 70.3 ± 6.2 | 54.5 ± 6.7 | 3.8 | 0.007 | 1.64 |
| b) 32 | 36 | −18 | 10 | 7.26 | ||||||
| Insula left BA13 | a) 22 | −36 | 0 | 12 | 8.28 | 66.7 ± 7.8 | 53.9 ± 9.3 | 3.4 | 0.010 | 0.91 |
| b) 40 | −36 | 22 | 8 | 8.06 | ||||||
| Thalamus left | 16 | −6 | −12 | 0 | 8.33 | 70.1 ± 8.8 | 57.4 ± 9.3 | 2.9 | 0.021 | 1.13 |
| BA4 right | 17 | 62 | −4 | 18 | 7.73 | 63.7 ± 6.6 | 53.0 ± 6.1 | 3.1 | 0.017 | 0.85 |
| BA6 left/Premotor area | a) 54 | −24 | 0 | 56 | 8.19 | 66.4 ± 9.1 | 49. 5 ± 6.1 | 4.9 | 0.002 | 1.89 |
| b) 31 | −26 | −10 | 52 | 7.13 | ||||||
| BA7 right | 15 | 26 | −76 | 48 | 9.25 | 46.2 ± 9.0 | 37.8 ± 8.3 | 3.3 | 0.014 | 0.64 |
| BA9 right | 13 | 6 | 40 | 20 | 7.06 | 79.0 ± 8.4 | 69.4 ± 8.4 | 1.8 | 0.109 | 0.67 |
| BA10 left | 42 | −18 | 62 | 20 | 10.65 | 65.1 ± 8.1 | 53.8 ± 8.8 | 3.1 | 0.017 | 0.91 |
| BA19* | 38 | −44 | −82 | 26 | 7.57 | 52.1 ± 7.3 | 43.2 ± 8.7 | 2.3 | 0.052 | 0.68 |
| BA22 left | 13 | −50 | 0 | 4 | 5.59 | 75.5 ± 6.0 | 60.0 ± 9.5 | 3.3 | 0.012 | 1.28 |
| BA24/vACC | 12 | 0 | −6 | 34 | 6.98 | 72.4 ± 8.6 | 62.1 ± 9.3 | 1.7 | 0.137 | 0.84 |
| BA40 left | 17 | −60 | −18 | 18 | 7.36 | 64.0 ± 6.1 | 53.2 ± 7.4 | 0.06 | 0.953 | 0.02 |
| BA43 right | 17 | 66 | −16 | 20 | 7.26 | 64.1 ± 8.1 | 53.5 ± 6.0 | 2.1 | 0.072 | 0.86 |
| BA45 left/Broca's area | 12 | −58 | 20 | 8 | 6.10 | 57.3 ± 8.2 | 42.6 ± 6.7 | 6.9 | 0.000 | 1.03 |
ASL, arterial spin labeling; BA, Brodmann area; CBF, cerebral blood flow; d, Cohens' d, effect size; a) and b) refer to independent clusters within the same region; BA19*, left associated visual cortex; vACC, ventral anterior cingulate cortex.