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. 2016 Jul 4;6(9):e00514. doi: 10.1002/brb3.514

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© 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Neonatal sevo treatment impaired learning and memory during periadolescence. (A) Locomotion of a no‐sevo‐ and a sevo‐treated mouse are represented by traces on the circular rotating platform. The arrow indicates the direction of platform movement (1 revolution per minute). Entrances into the shock zone (represented by the 60° red zone) are marked as the red dots. (B) At P27 and P28, sevo‐treated mice entered the shock zone significantly more compared to the no‐sevo–treated group during a total of 10 trials. Two‐way ANOVA was used for statistical calculation: F _{(1, 63)} = 1.28, P < 0.01 for treatment; F _(9, 63) = 14.6, P < 0.001 for trials; F _(9, 63) = 1.8, P > 0.05 for interaction between treatment and trials. Bonferroni posttests showed P < 0.05 for treatment on day 1, trials 4 and 5; day 2, trial 2. Asterisk (*) denotes P < 0.05 for treatment effect within the trials (N = 4 for no sevo, N = 5 for sevo).