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Power to detect significant associations among 1564 radiotherapy patientsa.
| Minor allele frequency |
|||||||
|---|---|---|---|---|---|---|---|
| 0.05 | 0.10 | 0.15 | 0.25 | 0.35 | 0.50 | ||
| Per-allele odds ratio | 1.15 | 0 | 0 | 0 | 0 | 0 | 0 |
| 1.25 | 0 | 0 | 0 | 1% | 1% | 1% | |
| 1.5 | 1% | 7% | 21% | 47% | 59% | 56% | |
| 2.0 | 64% | 99% | 100% | 100% | 100% | 100% | |
Assuming a type I error rate of 5 × 10− 8 and a disease prevalence of 20%, which was the approximate average prevalence of the toxicities included in the study.
