Table 6.
Urinary frequency multivariable analysis results (p < 5 × 10− 6).
| rsID | Chr | Minor allele | MAFa | RAPPER, N = 527 |
RADIOGEN, N = 477 |
Gene-PARE, N = 255 |
CCI, N = 150 |
Meta-analysis, N = 1409 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ORb (95% CIc) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | phetd | ||||
| rs17599026 | 5q31.2 | T | 0.08 | 2.57 (1.28,5.16) | 0.012 | 3.19 (1.57,6.46) | 2.36 × 10− 3 | 8.16 (3.04,21.9) | 5.88 × 10− 6 | 1.63 (0.59,4.54) |
0.358 | 3.12 (2.08,4.69) | 4.16 × 10− 8 | 0.139 |
| rs11574532 | 12q13.13 | T | 0.07 | 1.70 (0.70,4.33) | 0.282 | 3.69 (1.78,7.68) | 8.29 × 10− 4 | 3.57 (1.53,8.35) | 3.03 × 10− 3 | 5.76 (1.66,19.99) | 5.50 × 10− 3 | 3.25 (2.08,5.07) | 2.11 × 10− 7 | 0.420 |
| rs342442 | 4q22.1 | T | 0.38 | 0.39 (0.22,0.68) | 3.50 × 10− 4 | 0.56 (0.36,0.89) | 0.011 | 0.51 (0.32,0.8) | 2.88 × 10− 3 | 0.62 (0.31,1.25) |
0.174 | 0.51 (0.39,0.66) | 3.86 × 10− 7 | 0.700 |
| rs4534636 | 12p13.31 | A | 0.20 | 1.27 (0.71,2.27) | 0.429 | 2.48 (1.54,3.99) | 2.35 × 10− 4 | 2.06 (1.25,3.41) | 4.31 × 10− 3 | 2.03 (0.97,4.25) |
0.0461 | 1.96 (1.49,2.59) | 1.67 × 10− 6 | 0.373 |
| rs8098701 | 18q21.1 | T | 0.07 | 2.93 (1.39,6.15) | 7.63 × 10− 3 | 2.75 (1.52,4.97) | 1.15 × 10− 3 | 1.70 (0.86,3.34) | 0.133 | 2.53 (0.77,8.28) |
0.136 | 2.41 (1.68,3.47) | 2.11 × 10− 6 | 0.684 |
| rs7366282e | 1q41 | C | 0.06 | 2.22 (1.02,4.82) | 0.056 | 4.11 (1.82,9.3) | 1.27 × 10− 3 | 3.86 (1.55,9.63) | 3.03 × 10− 3 | NAf | NA | 3.20 (1.98,5.16) | 2.03 × 10− 6 | 0.501 |
| rs10209697 | 2q36.1 | A | 0.07 | 4.09 (1.65,10.1) | 4.35 × 10− 3 | 4.32 (2.19,8.5) | 5.14 × 10− 5 | 1.53 (0.74,3.14) | 0.255 | 1.36 (0.44,4.27) |
0.599 | 2.66 (1.77,3.99) | 2.27 × 10− 6 | 0.093 |
| rs4997823 | 6q14.1 | G | 0.35 | 0.40 (0.22,0.74) | 1.90 × 10− 3 | 0.37 (0.2,0.67) | 5.69 × 10− 4 | 0.68 (0.42,1.11) | 0.118 | 0.44 (0.20,0.99) |
0.040 | 0.49 (0.36,0.66) | 2.35 × 10− 6 | 0.372 |
| rs7356945 | 6p24.1 | T | 0.33 | 2.56 (1.58,4.13) | 1.10 × 10− 4 | 1.63 (1.08,2.48) | 0.022 | 1.21 (0.8,1.85) | 0.368 | 2.42 (1.25,4.69) |
7.32 × 10− 3 | 1.74 (1.38,2.21) | 3.71 × 10− 6 | 0.097 |
| rs6003982 | 22q11.23 | G | 0.44 | 0.67 (0.37,1.19) | 0.166 | 0.46 (0.27,0.79) | 3.70 × 10− 3 | 0.39 (0.23,0.67) | 4.33 × 10− 6 | 0.60 (0.30,1.19) |
0.138 | 0.51 (0.38,0.68) | 4.28 × 10− 6 | 0.549 |
| rs10101158 | 8q24.3 | A | 0.44 | 1.63 (0.95,2.81) | 0.074 | 1.56 (0.98,2.48) | 0.063 | 1.99 (1.3,3.06) | 1.24 × 10− 3 | 2.17 (1.14,4.11) |
0.015 | 1.80 (1.40,2.31) | 4.39 × 10− 6 | 0.792 |
a
MAF, minor allele frequency.
b
OR, odds ratio.
c
CI, confidence interval.
d
phet = p-value from chi-squared test of heterogeneity.
e
rs7366282 was not imputed in CCI.
f
NA, not available.