Table 7.
Decreased stream multivariable analysis results (p < 5 × 10− 6).
| rsID | Chr | Minor allele | MAFa | RAPPER, N = 512 |
RADIOGEN, N = 478 |
Gene-PARE, N = 255 |
Meta-analysis, N = 1245 |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ORb (95% CIc) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | phetd | ||||
| rs7720298 | 5p15.2 | G | 0.24 | 2.13 (1.21,3.74) | 0.010 | 3.63 (1.08,12.16) | 0.044 | 3.09 (1.9,5.04) | 2.34 × 10− 6 | 2.71 (1.90,3.86) | 3.21 × 10− 8 | 0.545 |
| rs17362923e | 8p23.2 | G | 0.18 | 3.60 (1.98,6.55) | 3.12 × 10− 5 | NAf | NA | 2.18 (1.29,3.66) | 3.20 × 10− 3 | 2.70 (1.83,4.00) | 6.79 × 10− 7 | 0.459 |
| rs76273496 | 1q31.3 | C | 0.07 | 4.02 (1.83,8.81) | 1.31 × 10− 3 | 3.69 (0.66,20.46) | 0.169 | 3.32 (1.43,7.68) | 5.13 × 10− 3 | 3.68 (2.13,6.33) | 2.71 × 10− 6 | 0.948 |
| rs2203205 | 23q21.1 | C | 0.29 | 1.70 (1.15,2.52) | 0.010 | 2.35 (0.97,5.74) | 0.054 | 1.71 (1.26,2.31) | 5.87 × 10− 4 | 1.74 (1.38,2.20) | 2.86 × 10− 6 | 0.790 |
| rs144596911 | 3q28 | A | 0.09 | 4.41 (2.09,9.28) | 2.38 × 10− 4 | 1.01 (0.09,11.12) | 0.995 | 3.28 (1.44,7.45) | 4.78 × 10− 3 | 3.60 (2.11,6.17) | 2.94 × 10− 6 | 0.493 |
| rs62091368 | 18p11.32 | A | 0.07 | 6.78 (2.26,20.37) | 1.26 × 10− 3 | 6.96 (1.71,28.3) | 0.015 | 2.66 (1.08,6.57) | 0.037 | 4.36 (2.33,8.14) | 3.95 × 10− 6 | 0.334 |
| rs141342719 | 5q23.3 | T | 0.12 | 5.39 (2.43,11.94) | 5.09 × 10− 5 | 1.35 (0.23,7.9) | 0.748 | 2.77 (1.27,6.07) | 0.012 | 3.50 (2.05,5.95) | 3.97 × 10− 6 | 0.273 |
| rs673783 | 18p11.32 | G | 0.31 | 2.88 (1.52,5.44) | 1.06 × 10− 3 | 2.28 (0.68,7.6) | 0.183 | 2.28 (1.33,3.91) | 3.24 × 10− 3 | 2.49 (1.69,3.67) | 4.33 × 10− 6 | 0.853 |
a
MAF, minor allele frequency.
b
OR, odds ratio.
c
CI, confidence interval.
d
phet = p-value from chi-squared test of heterogeneity.
e
For rs17362923, RADIOGEN MAF = 0.182; imputation info = 0.980. This SNP had a very large standard error in the RADIOGEN dataset, and so it was excluded from meta-analysis.
f
NA, not available.