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. Author manuscript; available in PMC: 2017 Sep 21.
Published in final edited form as: Neuron. 2016 Sep 21;91(6):1199–1218. doi: 10.1016/j.neuron.2016.09.006

Figure 3. Schematic of BFCN interaction with attention related circuitry.

Figure 3

Task oriented information from the PFC is transmitted to the basal forebrain, which signals to sensory cortex where cholinergic signaling causes decorrelation (Chen et al., 2015; Goard & Dan, 2009; Kalmbach et al., 2012; Kalmbach & Waters, 2014; Pinto et al., 2013; Runfeldt et al., 2014; Thiele et al., 2012; Kim et al., 2016) and enhances response reliability (Cohen & Maunsell, 2009; Mitchell et al. 2009). Once a task relevant stimulus is detected in the sensory cortex, cholinergic signaling from the basal forebrain to the PFC is stimulated and transient ACh release within the PFC signals cue detection (Sarter et al., 2016a; Parikh et al., 2007; Howe et al., 2013).