Table 1. Biological processes associated with HMGB4 expression.
| Term | Count | % | p-value | FDR |
|---|---|---|---|---|
| 293T cells HMGB4-EGFP overexpression | ||||
| GO:0007155 ~ cell adhesion | 44 | 7.82 | 0.000002 | 0.003 |
| GO:0022610 ~ biological adhesion | 44 | 7.82 | 0.000002 | 0.003 |
| PIRSF002048:histone H2A | 7 | 1.24 | 0.000003 | 0.004 |
| GO:0001568 ~ blood vessel development | 22 | 3.91 | 0.000007 | 0.013 |
| IPR002119:Histone H2A | 7 | 1.24 | 0.000009 | 0.014 |
| GO:0000786 ~ nucleosome | 11 | 1.95 | 0.000012 | 0.016 |
| GO:0001944 ~ vasculature development | 22 | 3.91 | 0.000011 | 0.019 |
| SM00414:H2A | 7 | 1.24 | 0.000022 | 0.027 |
| citrullination | 7 | 1.24 | 0.000021 | 0.030 |
| IPR007125:Histone core | 9 | 1.60 | 0.000030 | 0.046 |
| repeat:TNFR-Cys 3 | 7 | 1.24 | 0.000029 | 0.048 |
| Human brain endogenous HMGB4 | ||||
| GO:0005576 ~ extracellular region | 73 | 16.01 | 0.000030 | 0.040 |
HMGB4-EGFP and EGFP -expressing HEK 293T -cell clones were subjected to microarray gene expression analysis. Expression data of human brain tissue samples was obtained from Medisapiens Ltd. Expression data was analyzed with the PANTHER software to detect changes in the gene expression related to various biological processes. Percent of gene hits against total were calculated. Clusters and subclusters with highest values are shown in detail.