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. Author manuscript; available in PMC: 2016 Nov 25.
Published in final edited form as: J Nat Prod. 2015 Oct 23;78(11):2657–2665. doi: 10.1021/acs.jnatprod.5b00603

Figure 1.

Figure 1

Schematic workflow for ligand fishing with N-terminus-coupled α-glucosidase magnetic beads combined with HPLC-HRMS-SPE-NMR analysis of E. catharinae extract. Path 1: Ligand fishing with α-glucosidase enzyme immobilized on magnetic beads followed by LC-HRMS analysis of both the crude extract and potential ligands fished out of the extract. Path 2: HPLC-HRMS-SPE-NMR analysis targeting potential α-glucosidase ligands pinpointed in the preceding ligand fishing experiment.