Table 3.
Adverse effects and drug used as rescue treatment in three study groups
| Variable | Placebo group, N=50 | Pethidine 5 mg group, N=50 | Pethidine 10 mg group, N=50 | Total, N=150 |
P-value (95% CI) |
|---|---|---|---|---|---|
| Hypotension; n (%) | 34 (68) | 33 (66) | 37 (74) | 104 (69.3) | 0.66 (61.9–76.7) |
| Bradycardia; n (%) | 3 (6) | 0 (0) | 1 (2) | 4 (2.7) | 0.17 (0.1–5.3) |
| Nausea; n (%) | 19 (38) | 25 (50) | 27 (54) | 71 (47.3) | 0.25 (39.3–55.3) |
| Vomiting; n (%) | 6 (12) | 13 (26) | 13 (26) | 32 (21.3) | 0.14 (14.7–27.8) |
| Pruritus; n (%) | 0 (0) | 3 (6) | 13 (26) | 16 (10.7) | 0.01 (5.7–15.6) |
| Prescripted ephedrine; n (%) | 34 (68) | 33 (66) | 37 (74) | 104 (69.3) | 0.09 (61.9–76.7) |
| Prescripted atropine; n (%) | 3 (6) | 0 (0) | 1 (2) | 4 (2.7) | 0.17 (0.1–5) |
| Prescripted ondansetron; n (%) | 8 (16) | 18 (36) | 19 (38) | 45 (30) | 0.03 (22.7–37.3) |
| Prescripted pethidine; n (%) | 8 (16) | 2 (4) | 0 (0) | 10 (6.7) | 0.004 (3–10) |
Abbreviation: CI, confidence interval.