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. 2016 Sep 20;11:4799–4818. doi: 10.2147/IJN.S111736

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© 2016 Freag et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cytotoxicity analysis of free AE, AE-LCNPs, AE-PEGylated LCNPs (F13), and blank LCNPs on MCF-7 cells at the concentration of 5–90 µM after 24 hours (A) and 48 hours (B). Data are represented as mean ± SD (n=3), P<0.05. (C) Cellular uptake amount of free AE, AE-LCNPs (F6), and AE-PEG-LCNPs (F13) by MCF-7 cells at fixed AE concentration of 5 µM within 24 hours. Data are represented as mean ± SD (n=3), P<0.05.

Abbreviations: AE, aloe-emodin; LCNPs, liquid crystalline nanoparticles; PEG, polyethylene glycol; SD, standard deviation.