Table 2.
Physicochemical characteristics of the prepared LCNPs and PEGylated LCNPs
| Formula | %EE | PS (nm) | PDI | ZP (mV) |
|---|---|---|---|---|
| F1 | – | 190.25±5.10 | 0.63±0.01 | −29.80±2.14 |
| F2 | – | 154.14±6.30 | 0.19±0.01 | −32.30±1.15 |
| F3 | – | 150.23±2.10 | 0.21±0.01 | −31.90±2.18 |
| F4 | 99.50%±0.50 | 182.30±2.23 | 0.25±0.04 | −31.70±1.14 |
| F5 | 97.50%±2.50 | 175.40±4.21 | 0.20±0.05 | −30.20±2.34 |
| F6 | 95.30%±4.10 | 155.03±4.43 | 0.13±0.01 | −29.30±1.05 |
| F6-2a | 71.00%±4.50 | 228.00±4.23 | 0.73±0.06 | −38.00±2.06 |
| F7 | 60.00%±2.50 | 156.50±5.03 | 0.19±0.07 | −33.00±0.04 |
| F8 | 58.50%±3.20 | 158.00±6.33 | 0.18±0.10 | −34.00±1.18 |
| F9 | 95.10%±3.20 | 163.00±3.73 | 0.26±0.02 | −33.50±2.11 |
| F10 | 95.20%±4.10 | 159.00±5.03 | 0.16±0.11 | −30.80±3.32 |
| F11 | 96.30%±3.60 | 158.00±3.93 | 0.19±0.06 | −42.90±1.02 |
| F12 | 97.30%±2.50 | 220.00±4.22 | 0.32±0.05 | −35.00±3.22 |
| F13 | 96.00%±2.30 | 190.00±3.13 | 0.36±0.04 | −49.90±0.90 |
| F14 | 98.20%±1.90 | 240.00±5.00 | 0.49±0.05 | −62.00±1.34 |
Notes:
a
F6-2, prepared by thin film hydration technique. Data is displayed as mean ± SD.
Abbreviations: %EE, entrapment efficiency; LCNPs, liquid crystalline nanoparticles; PDI, polydispersity index; PEG, polyethylene glycol; PS, particle size; ZP, zeta potential.