Table 5.
Pharmacokinetic parameters of free AE and its LC dispersions after IP injection in healthy rats (mean ± SD, n=6)
| Parameters | Free AE | AE-LCNPs | AE-PEG-LCNPs |
|---|---|---|---|
| Cmax (µg/mL) | 1.24±0.54 | 2.58±0.50 | 3.56±0.91 |
| Tmax (minutes) | 5±0.93 | 5±1.00 | 5±0.89 |
| t1/2 (minutes) | 27.68±8.12 | 18.4±4.23 | 123.8±10.23 |
| AUC0→∞ (µg/mL⋅min) | 50.29±5.87 | 110.63±8.76 | 274.27±11.20 |
| MRT∞ (minutes) | 40.68±6.78 | 27.28±9.11 | 175.62±11.32 |
| Kel (minute−1) | 0.025±0.002 | 0.037±0.001 | 0.005±0.001 |
| CL (mL/min·kg) | 0.15±0.010 | 0.067±0.00 | 0.027±0.00 |
Note: Data is displayed as mean ± SD.
Abbreviations: AE, aloe-emodin; AUC, area under the curve; CL, clearance; IP, intraperitoneal; LC, liquid crystalline; LCNPs, LC nanoparticles; MRT, mean residence time; PEG, polyethylene glycol; SD, standard deviation; Cmax, peak plasma concentration; Kel, elimination rate constant; t1/2, half-life; Tmax, time to reach the maximum plasma concentration.