Table 6.
Effect of free AE, AE-LCNPs, and AE-PEG-LCNPs on animals’ nutritional state
| Treatment (mg/kg per day) | %weight change | Food consumption (g/day)
|
Water consumption (mL/day)
|
||
|---|---|---|---|---|---|
| Day 0 | Day 7 | Day 0 | Day 7 | ||
| Negative control | 5.53±3.68 | 23.0±1.41 | 23.45±0.21 | 21.0±1.41 | 22.50±0.71 |
| Free AE | 1.03±6.49 | 22.10±2.97 | 23.35±0.07 | 21.0±1.41 | 23.50±0.71 |
| AE-LCNPs | 4.86±1.17 | 22.20±2.97 | 22.75±1.06 | 21.50±2.12 | 24.50±0.71 |
| AE-PEG-LCNPs | 4.0±4.06 | 23.05±2.76 | 23.60±0.14 | 21.0±1.41 | 24.50±0.71 |
Notes: The study was performed on Wistar rats model of six animals in each group (n=6). Values are expressed as mean ± SD. Weight change (%): (F=1.284, P=0.307); food consumption at day 0: (F=0.076, P=0.970); food consumption at day 7: (F=0.930, P=0.504); water consumption at day 0: (F=0.048, P=0.984); water consumption at day 7: (F=3.667, P=0.121). F, F-test (ANOVA) followed by post hoc test (Scheffe). Free AE, AE solution (7.5 mg/kg per day); AE-LCNPs, AE-loaded LCNPs; AE-PEG-LCNPs, AE-loaded PEGylated LCNPs (equivalent to AE concentration of 7.5 mg/kg per day and total lipids of 555 mg/kg per day).
Abbreviations: AE, aloe-emodin; ANOVA, analysis of variance; LCNPs, liquid crystalline nanoparticles; PEG, polyethylene glycol; SD, standard deviation.