Table S1.
Physicochemical properties of freeze-dried AE-LCNPs and AE-PEGylated LCNPs
| Parameters | AE-LCNPs | Freeze-dried AE-LCNPs | AE-PEG-LCNPs | Freeze-dried AE-PEG-LCNPs |
|---|---|---|---|---|
| Physical appearance | – | Intact fluffy cake | – | Intact fluffy cake |
| Reconstitution time | – | 2 minutes | – | 2 minutes |
| PS (nm) | 155.03±4.43 | 147.00±3.00 | 190.00±3.13 | 203.00±8.14 |
| (Sf/Si)a | – | 0.95 | – | 1.06 |
| PDI | 0.13±0.01 | 0.30±0.09 | 0.36±0.04 | 0.31±0.05 |
| ZP (mV) | −29.30±1.05 | −30.00±1.00 | −49.90±0.90 | −51.00±2.07 |
| %EE (% w/w) | 95.30%±4.10 | 94.5%±1.00 | 96.00%±2.30 | 96.01%±2.11 |
Note:
a
Sf/Si is the ratio between PS after lyophilization and initial one.
Abbreviations: AE, aloe-emodin; %EE, entrapment efficiency; LCNPs, liquid crystalline nanoparticles; PDI, polydispersity index; PEG, polyethylene glycol; PS, particle size; ZP, ζ-potential.