Table 4.
Univariate and multivariate analysis of clinicopathlogical parameters with OS and DFS by Cox proportional hazards regression
| Factors | Univariate
|
Multivariate
|
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | |
| OS | ||||||
| Age | 0.980 | 0.956–1.005 | 0.115 | |||
| Size | 1.605 | 0.764–3.374 | 0.212 | |||
| Histological type | 0.730 | 0.175–3.049 | 0.666 | |||
| Menopausal status | 0.384 | 0.183–0.808 | 0.012 | 0.348 | 0.112–1.085 | 0.069 |
| Pathological grade | 3.694 | 1.716–7.956 | 0.001 | 1.549 | 0.667–3.598 | 0.309 |
| LN metastasis | 11.972 | 3.647–39.300 | <0.001 | 7.193 | 1.747–29.619 | 0.006 |
| TNM stage | 4.087 | 2.554–6.566 | <0.001 | 2.222 | 1.191–4.146 | 0.012 |
| NEDD9 | 5.055 | 1.209–21.139 | 0.026 | 4.554 | 1.028–20.170 | 0.046 |
| E-cadherin | 0.357 | 0.155–0.824 | 0.016 | 0.355 | 0.146–0.883 | 0.022 |
| DFS | ||||||
| Age | 0.976 | 0.954–0.999 | 0.139 | |||
| Size | 1.244 | 0.647–2.394 | 0.512 | |||
| Histological type | 0.280 | 0.038–2.036 | 0.208 | |||
| Menopausal status | 0.372 | 0.188–0.734 | 0.004 | 0.453 | 0.168–1.225 | 0.119 |
| Pathological grade | 2.910 | 1.493–5.669 | 0.002 | 1.153 | 0.574–2.318 | 0.689 |
| LN metastasis | 11.419 | 4.047–32.222 | <0.001 | 4.760 | 1.636–13.844 | 0.004 |
| TNM stage | 4.287 | 2.685–6.845 | <0.001 | 2.630 | 1.481–4.670 | 0.001 |
| NEDD9 | 2.928 | 1.040–8.245 | 0.042 | 3.604 | 1.205–10.779 | 0.022 |
| E-cadherin | 0.413 | 0.202–0.843 | 0.015 | 0.415 | 0.192–0.897 | 0.025 |
Abbreviations: CI, confidence interval; DFS, disease-free survival; LN, lymph node; NEDD9, neural precursor cell expressed, developmentally downregulated 9; OS, overall survival; TNM, tumor-node-metastasis; OR, odds ratio.