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Short-term (2 or 5 weeks) As exposure causes changes in SYN expression in mouse brain. Immunohistochemical analysis shows increased SYN (brown) staining in the cortex (A–C) and striatum (D–F) (Bregma Zero) of mice exposed to 100 ppb As, counterstained with hematoxylin/eosin (purple/pink). A, Control cortex, B, 2 week As exposure [cortex], C, 5 week As exposure [cortex], D, control striatum, E, 2 week As exposure [striatum], and F, 5 week As exposure [striatum]. Scale bar = 10 μm.
