FIG. 6.

Short-term (2 or 5 weeks) As exposure results in the oligomerization of SYN, and increases in ubiquitinylated proteins and LC3 expression in mouse brain. Western blot analysis with densitometry of tissue showing increased SYN oligomerization and increased UB and LC3 from mice exposed to 100 ppb arsenic for 2 weeks or 5 weeks. A, Western blot staining for SYN, UB, LC3, TH, and GAPDH. B, Densitometric analysis of the Western blots, normalized to GAPDH. One-way ANOVA with Tukey’s multiple comparison tests; *significant difference from control animals (*P < .05, **P < .01, ***P < .001) and #significant difference from 2 week treated animals (#P < .05).