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. 2016 Jul 13;153(2):341–351. doi: 10.1093/toxsci/kfw126

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© The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 5 — The effect of flutamide (A), 2-hydroxyflutamide (B), and bicalutamide (C) exposure on ATP content and cytotoxicity of HepG2 cells (2 h) compared with vehicle control. Serial concentrations of compounds were used up to 300 µM in glucose or galactose media. ATP values are expressed as a percentage of those of the vehicle control, LDH release is expressed as extracellular LDH as a % of total LDH. Statistical significance compared with vehicle control; glucose *P < .05; **P < .01; ***P < .001, galactose ⁺P < .05; ⁺⁺P < .01; ⁺⁺⁺P < .001, between glucose and galactose ^P < .05; ^ ^P < .01; ^ ^ ^P < .001. All results were normalized to µg protein per well. Data are presented as mean ± SEM of n = 3 experiments.