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The effect of flutamide and 2-hydroxyflutamide exposure on the activity of mitochondrial respiratory complexes I (A), II (B), and IV (C) in uncoupled, permeabilized HepG2 cells. Compounds were used at 10–250 µM. Statistical significance compared with vehicle control; * P < .05; ** P <.01; *** P <.001. All results were normalized to µg protein per well. Calculation of changes in complex activity is described in Figure 3. Data are presented as mean + SEM of n = 3 experiments.
