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. 2016 Jul 13;153(2):341–351. doi: 10.1093/toxsci/kfw126

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© The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 8 — The effect of flutamide and 2-hydroxyflutamide exposure on the activity of mitochondrial respiratory complexes I (A), II (B), III (C), and V (D) in permeabilized HepG2 cells. Compounds were used at 10–250 µM. Statistical significance compared with vehicle control; * P < .05; ** P <.01; *** P <.001. Complex I, II, and III activity were defined as complex I, II, or III-stimulated maximal respiration, respectively, compared with vehicle control. Complex V activity was defined as the difference in compound-induced OCR change between coupled and uncoupled cells relative to vehicle control. All results were normalized to µg protein per well. Data are presented as mean + SEM of n = 3 experiments.