TABLE 3.
Gene Expression Changes that were Uniquely Regulated by PCN, Uniquely Regulated by TCPOBOP, or Regulated by Both PCN and TCPOBOP at 60-Day of Age in the Livers of WT Mice (with >2-Fold Change and Adjusted P <0.05)
| Comparison Group | Regulation | Gene Symbol | Description |
|---|---|---|---|
| PCN vs CO TCPOBOP vs CO (common) | Up-regulated | Cyp2b13 | Cytochrome P450, family 2, subfamily b, polypeptide 13 |
| Down-regulated | Cyp4a10; Cyp4a31 | Cytochrome P450, family 4, subfamily a, polypeptide 10 or 31 | |
| Afp | Alpha fetoprotein | ||
| Up-regulated by TCPOBOP, down-regulated by PCN | Serpinb1a | Serine (or cysteine) peptidase inhibitor, clade B, member 1a | |
| PCN vs CO (Unique) | Up-regulated | Cxcl1 | Chemokine (C-X-C motif) ligand 1 |
| Mir378c | microrna mir-378c | ||
| Saa2 | Serum amyloid A 2 | ||
| Saa1 | Serum amyloid A 1 | ||
| Zbtb16 | Zinc finger and BTB domain containing 16 | ||
| Steap4 | STEAP family member 4 | ||
| Dbp | D site albumin promoter binding protein | ||
| Asns | Asparagine synthetase | ||
| Down-regulated | Irs2 | Insulin receptor substrate 2 | |
| Cyp4a31 | Cytochrome P450, family 4, subfamily a, polypeptide 31 | ||
| Igfbp1 | Insulin-like growth factor binding protein 1 | ||
| Osgin1 | Oxidative stress induced growth inhibitor 1 | ||
| Igfbp2 | Insulin-like growth factor binding protein 2 | ||
| Npas2 | Neuronal PAS domain protein 2 | ||
| Cyp4a32 | Cytochrome P450, family 4, subfamily a, polypeptide 32 | ||
| Arntl | Aryl hydrocarbon receptor nuclear translocator-like | ||
| Cyp4a14 | Cytochrome P450, family 4, subfamily a, polypeptide 14 | ||
| TCPOBOP vs CO (Unique) | Up-regulated | Cyp2b10 | Cytochrome P450, family 2, subfamily b, polypeptide 10 |
| Cyp2c55 | Cytochrome P450, family 2, subfamily c, polypeptide 55 | ||
| Cyp2c29 | cytochrome P450, family 2, subfamily c, polypeptide 29 | ||
| Gna14 | Guanine nucleotide binding protein, alpha 14 | ||
| Cyp26a1 | Cytochrome P450, family 26, subfamily a, polypeptide 1 | ||
| Orm3 | Orosomucoid 3 | ||
| Gstm3 | Glutathione S-transferase, mu 3 | ||
| Dhrs9 | Dehydrogenase/reductase (SDR family) member 9 | ||
| Sult5a1 | Sulfotransferase family 5A, member 1 | ||
| Mup-ps16 | Major urinary protein, pseudogene 16 | ||
| AF357426 | snoRNA AF357426 | ||
| 2310067E19Rik | RIKEN cDNA 2310067E19 gene | ||
| Prss8 | Protease, serine 8 (prostasin) | ||
| Tmeff2 | Transmembrane protein with EGF-like and two follistatin-like domains 2 | ||
| Cyp2c66 | Cytochrome P450, family 2, subfamily c, polypeptide 66 | ||
| Slc3a1 | Solute carrier family 3, member 1 | ||
| Mir493 | microRNA 493 | ||
| Klk1b4 | Kallikrein 1-related pepidase b4 | ||
| Cyp2c65 | Cytochrome P450, family 2, subfamily c, Polypeptide 65 | ||
| Prg4 | Proteoglycan 4 | ||
| Kcnk1 | Potassium channel, subfamily K, member 1 | ||
| Ccl9 | Chemokine (C-C motif) ligand 9 | ||
| DQ267102 | snoRNA DQ267102 | ||
| Rarres1 | Retinoic acid receptor responder (tazarotene induced) 1 | ||
| Down-regulated | Snord14e | Small nucleolar RNA, C/D box 14E |