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2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)–induced suppression of IgM response in primary human B cells. Increasing levels of TCDD induces a dose-dependent decrease in the number of IgM-secreting cells (A; n = 51) and the concentration of IgM secreted into culture medium (B; n = 49). *P < .05 as compared with the vehicle Error bars indicate SEM response. Abbreviation: ELISPOT, enzyme-linked immunospot.
