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. 2016 Jul 29;153(2):372–381. doi: 10.1093/toxsci/kfw133

FIG. 4.

FIG. 4.

OPTN expression in the substantia nigra increases in pre-clinical and end-stage PD models. Representative images of nigral dopamine neurons stained for OPTN in Lewis rats treated with DMSO (control; A, E, F) or 3.0 mg/kg/day rotenone i.p. for 24 h (B, G, H), 5 days (C, I, J), or until end-stage behavioral phenotype (D, K, L) to model different stages of PD, respectively. (A–D) Low magnification (×20) representative images of OPTN-positive cells in the substantia nigra pars compacta of rats from each stage. (E–L) High magnification (×60) representative images of OPTN-positive cells in the substantia nigra pars compacta region of rats from each stage. Scale bar = 50 μm (A–D), 10 μm (E–L).