Figure 1.
Adenocarcinoma in situ in a 44-year-old woman.
Notes: (A) A solitary ground-glass opacity nodule on the superior lobe of left lung was found at the time of her health checkup. She was a nonsmoker, did not have any individual history of cancer and no family history of cancer, and her blood tumor markers were negative. (B) On reexamination by HRCT after 3 months, no obvious change was noted. Hence, she decided to undergo surgical resection. Pathological diagnosis indicated that she had adenocarcinoma in situ. Immunohistochemistry: ALK-V (−), ROS-1 (−). (C) Low-magnification (hematoxylin and eosin, original magnification ×40) photomicrograph demonstrates uniform cuboidal cell proliferation (arrows) involving thickened alveolar walls (lepidic tumor growth). (D) High magnification of (C) (original magnification ×200).
Abbreviations: ALK, anaplastic lymphoma kinase; HRCT, high-resolution computed tomography.