Figure 2.

Minimally invasive adenocarcinoma in a 55-year-old woman.

Notes: (A) A solitary ground-glass opacity nodule on the superior lobe of right lung was observed at the time of her health checkup. She was a nonsmoker, did not have any individual history of cancer and no family history of cancer, and the level of her blood tumor markers CEA was 5.34 ng/mL. She underwent reexamination by HRCT two times and no obvious change was noted (B and C). Afterward, she decided to undergo surgical resection. Pathological diagnosis indicated that she had a minimally invasive adenocarcinoma. Immunohistochemistry: ALK-V (−), ROS-1 (−). (D) Low magnification photomicrographs (hematoxylin and eosin, original magnification ×40) demonstrates lesion consisting of predominantly lepidic tumor growth with several foci (arrows) of invasive acinar components <5 mm in thickness. (E) High magnification of (D) (original magnification ×200).

Abbreviations: ALK, anaplastic lymphoma kinase; HRCT, high-resolution computed tomography.