Table S1.
Comparison of features between patients with benign GGNs and adenocarcinomas
| Characteristics | Number of patients (%)
|
|
|---|---|---|
| Benign GGNs (14) | Adenocarcinomas (81) | |
| Sex | ||
| Female | 9 (64.3) | 55 (67.9) |
| Male | 5 (35.7) | 26 (32.1) |
| Age (45 years, 12) | ||
| Range (median) | 38–75 (57.1) | 30–84 (55.9) |
| <65 | 11 (78.6) | 53 (65.4) |
| ≥65 | 3 (21.4) | 28 (34.6) |
| Smoking habits | ||
| Current/former smoker | 3 (21.4) (all males) | 17 (21.0) (all males) |
| Nonsmoker | 11 (78.6) | 64 (79.0) |
| History of cancer | ||
| Yes | 1 (7.1) | 4 (4.9) |
| No | 13 (92.9) | 77 (95.1) |
| Family history of cancer | ||
| Yes/lung cancer | 0 | 17 (21)/8 (9.9) |
| No | 14 | 64 (79) |
| Blood tumor markers | ||
| CEA (+) | 0 | 15 (18.3) |
| CA125 (+) | 1 (0.1) | 7 (8.5) |
| CA19-9 (+) | 0 | 14 (17.1) |
| NSE (+) | 1 (0.1) | 17 (20.7) |
| CRFR21-1 (+) | 0 | 9 (11.0) |
| Nodular density | ||
| pGGNs | 9 (64.3) | 35 (43.2) |
| mGGNs | 5 (35.7) | 46 (56.8) |
| Size (mean ± standard deviation, cm) | 0.88±0.46 | 1.98±0.85 |
| Locations (HRCT) | ||
| RUL | 3 (21.4) | 35 (43.2) |
| RML | 3 (21.4) | 4 (4.9) |
| RLL | 2 (14.3) | 10 (12.4) |
| LUL | 5 (35.7) | 26 (32.1) |
| LLL | 1 (7.1) | 6 (7.4) |
Abbreviations: GGNs, ground-glass opacity nodule; pGGN, pure ground-glass opacity nodule; mGGN, mixed ground-glass opacity nodule; RUL, superior lobe of right lung; RML, middle lobe of right lung; RLL, inferior lobe of right lung; LUL, superior lobe of left lung; LLL, inferior lobe of left lung; NSE, neuron specific enolase.