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Vaccinia virus armed with transgenes for cancer therapy.
Notes: Insertion and deletion in the genome of the vaccinia virus makes it suitable for antitumor activity. Disruption of the viral thymidine kinase and deletion of vaccinia growth factor genes favors viral replication in cancer cells. Similarly, the virus can be equipped with various transgenes for specific activities that enhance the destruction of cancer cells.
Abbreviation: scAbs, single-chain antibodies.
