Figure 3.

Searching parameters used in the model calculation. (A) Parameters for the optimal positioning of tropomyosin (white) around the fiber axis which is denoted by a star mark. r and θ are the radial distance and the azimuthal angle of tropomyosin around the fiber axis, respectively. The zero positions for the parameters are defined in the text. The positive direction of r is away from the fiber axis and the clockwise rotation is positive for θ. (B) Parameters used for the optimal positioning of the troponin core domain (left). r and θ are the radial distance and the azimuthal angle of the troponin core domain around the fiber axis, respectively. The parameters α, β and γ are the rotation angle around the x, y and z Cartesian coordinates, respectively. The N-terminus of the troponin core domain is located so that it connects with the C-terminus of TNT1 (right). The loci of these termini are depicted by red circles. The variable range of each parameter is given in Table1. F-actin is shown by blue balls, in which four subdomains of an actin molecule15 are colored by red (subdomain 1), orange (subdomain 2), magenda (subdomain 3) and pink (subdomain 4). Tropomyosin is shown by the two strands of white balls and the troponin three subunits are shown by light blue (TNC), green (TNI) and yellow balls (TNT).