Table 2.
Association of selected T2DM-related SNPs with T2DM risk.
| No. | SNP rs# | Gene | Frequency of Risk Allele | Crude Model | Adjusted Model * | |||
|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95% CI) | p | OR (95% CI) | p | |||
| 1 | rs17106184 | FAF1 | 0.12 | 0.06 | 1.91 (1.36–2.69) | <0.0001 | 2.22 (1.53–3.24) | <0.0001 |
| 2 | rs780094 | GCKR | 0.53 | 0.52 | 0.96 (0.80–1.17) | 0.71 | 0.95 (0.77–1.17) | 0.60 |
| 3 | rs3773159 | MGLL | 0.12 | 0.10 | 1.16 (0.86–1.56) | 0.33 | 1.04 (0.75–1.45) | 0.82 |
| 4 | rs4402960 | IGF2BP2 | 0.25 | 0.25 | 1.02 (0.82–1.26) | 0.89 | 1.05 (0.83–1.34) | 0.67 |
| 5 | rs1470579 | IGF2BP2 | 0.27 | 0.26 | 1.04 (0.84–1.28) | 0.75 | 1.07 (0.85–1.36) | 0.55 |
| 6 | rs702634 | ARL15 | 0.90 | 0.89 | 0.89 (0.66–1.20) | 0.45 | 0.77 (0.55–1.08) | 0.13 |
| 7 | rs4712523 | CDKAL1 | 0.57 | 0.55 | 0.92 (0.77–1.11) | 0.41 | 0.84 (0.69–1.04) | 0.11 |
| 8 | rs4712524 | CDKAL1 | 0.57 | 0.55 | 0.91 (0.75–1.11) | 0.33 | 0.84 (0.68–1.03) | 0.10 |
| 9 | rs10946398 | CDKAL1 | 0.57 | 0.56 | 0.94 (0.78–1.14) | 0.55 | 0.87 (0.71–1.07) | 0.18 |
| 10 | rs7756992 | CDKAL1 | 0.49 | 0.48 | 1.06 (0.88–1.28) | 0.55 | 1.13 (0.92–1.39) | 0.26 |
| 11 | rs3130501 | POU5F1-TCF19 | 0.70 | 0.68 | 0.91 (0.74–1.11) | 0.35 | 0.81 (0.64–1.01) | 0.06 |
| 12 | rs9472138 | VEGFA | 0.91 | 0.90 | 0.88 (0.64–1.20) | 0.41 | 0.75 (0.53–1.07) | 0.11 |
| 13 | rs864745 | JAZF1 | 0.27 | 0.24 | 1.17 (0.94–1.45) | 0.16 | 1.13 (0.89–1.43) | 0.32 |
| 14 | rs13266634 | SLC30A8 | 0.42 | 0.42 | 1.02 (0.85–1.24) | 0.81 | 0.96 (0.78–1.18) | 0.68 |
| 15 | rs10811661 | CDKN2B | 0.54 | 0.52 | 0.91 (0.75–1.09) | 0.31 | 0.88 (0.71–1.08) | 0.21 |
| 16 | rs12779790 | CDC123/CAMKID | 0.85 | 0.84 | 0.89 (0.69–1.16) | 0.39 | 0.83 (0.62–1.11) | 0.20 |
| 17 | rs7923837 | HHEX | 0.78 | 0.77 | 0.96 (0.76–1.20) | 0.69 | 1.01 (0.79–1.30) | 0.91 |
| 18 | rs7903146 | TCF7L2 | 0.09 | 0.09 | 1.01 (0.63–1.62) | 0.97 | 1.05 (0.63–1.74) | 0.86 |
| 19 | rs1153188 | DCD | 0.09 | 0.09 | 1.21 (0.60–2.45) | 0.60 | 1.32 (0.58–2.96) | 0.51 |
| 20 | rs1370176 | C2CD4A/B | 0.30 | 0.29 | 1.02 (0.83–1.25) | 0.88 | 0.98 (0.78–1.23) | 0.87 |
| 21 | rs1436953 | C2CD4A/B | 0.36 | 0.35 | 1.06 (0.87–1.28) | 0.59 | 1.02 (0.82–1.27) | 0.85 |
| 22 | rs8050136 | FTO | 0.13 | 0.11 | 1.26 (0.94–1.69) | 0.12 | 1.16 (0.84–1.60) | 0.37 |
| 23 | rs7192960 | MAF/WWOX | 0.29 | 0.29 | 1.06 (0.82–1.24) | 0.97 | 1.07 (0.85–1.34) | 0.59 |
| 24 | rs75493593 | SLC16A11 | 0.13 | 0.12 | 1.13 (0.85–1.49) | 0.41 | 1.14 (0.84–1.56) | 0.39 |
| 25 | rs75418188 | SLC16A11 | 0.13 | 0.12 | 1.11 (0.84–1.47) | 0.46 | 1.23 (0.83–1.53) | 0.45 |
| 26 | rs13342232 | SLC16A11 | 0.14 | 0.12 | 1.11 (0.83–1.45) | 0.51 | 1.11 (0.82–1.52) | 0.49 |
| 27 | rs13342692 | SLC16A11 | 0.13 | 0.13 | 1.08 (0.82–1.43) | 0.58 | 1.09 (0.80–1.48) | 0.58 |
| 28 | rs117767867 | SLC16A11 | 0.13 | 0.13 | 1.06 (0.81–1.40) | 0.67 | 1.06 (0.78–1.44) | 0.71 |
OR: odds ratio; 95% CI: 95% confidence interval; * Adjusted for age, sex, body mass index (BMI), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP).