Table 4.
Stratified analysis between the genotypes of H19 rs2067051 and the risk of coal workers’ pneumoconiosis (CWP).
| Variables | Cases/Controls | Genotypes (Cases/Controls) | OR (95%CI) a | p a | |||
|---|---|---|---|---|---|---|---|
| CC | CT/TT | ||||||
| N | % | N | % | ||||
| Total | 695/691 | 563/511 | 81.0/74.0 | 132/180 | 19.0/26.0 | 0.64 (0.49–0.83) | 0.001 |
| Exposure Years | |||||||
| <25 | 315/322 | 256/246 | 81.3/76.4 | 59/76 | 18.7/23.6 | 0.63 (0.42–0.95) | 0.026 |
| ≥25 | 380/369 | 307/265 | 80.8/71.8 | 73/104 | 19.2/28.2 | 0.57 (0.40–0.80) | 0.001 |
| Smoking Status | |||||||
| Never | 368/335 | 300/240 | 81.5/71.6 | 68/95 | 18.5/28.4 | 0.55 (0.39–0.79) | 0.001 |
| Ever | 327/356 | 263/271 | 80.4/76.1 | 64/85 | 19.6/23.9 | 0.75 (0.51–1.10) | 0.138 |
| Pack-Years Smoked | |||||||
| 0 | 368/335 | 300/240 | 81.5/71.6 | 68/95 | 18.5/28.4 | 0.55 (0.39–0.79) | 0.001 |
| >0–20 | 199/163 | 158/123 | 79.4/75.5 | 41/40 | 20.6/24.5 | 0.76 (0.46–1.27) | 0.297 |
| >20 | 128/193 | 105/148 | 82.0/76.7 | 23/45 | 18.0/23.3 | 0.70 (0.39–1.25) | 0.223 |
| Stage | |||||||
| I | 426/691 | 352/511 | 82.6/74.0 | 74/180 | 17.4/26.0 | 0.63 (0.46–0.86) | 0.004 |
| II | 207/691 | 160/511 | 77.3/74.0 | 47/180 | 22.7/26.0 | 0.69 (0.47–1.02) | 0.061 |
| III | 62/691 | 51/511 | 82.3/74.0 | 11/180 | 17.7/26.0 | 0.51 (0.25–1.03) | 0.060 |
a Adjusted for age, exposure years, pack-years smoked, and job type in logistic regression model.