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. 2016 Jan 28;17(4):371–380. doi: 10.1080/15384047.2016.1139268

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© 2016 Threshold Pharmaceuticals

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Figure 2. — Antitumor activity of evofosfamide or ifosfamide in combination with docetaxel in the metastatic H460 intrapleural model. A, metastasis progression and tumor hypoxia characterization on 4 days, 8 days, and 12 d after H460 cells inoculation. Top panel, H & E staining; middle panel, enlarged images of inserts; and bottom panel, immunofluorescence staining of pimonidazole, a marker of hypoxia, on the consecutive sections of middle panel; green, hypoxia; blue, Hoechst 33342; and red, propidium iodide; B, Kaplan-Meier plot analysis of evofosfamide or ifosfamide as monotherapy. C, Kaplan-Meier plot analysis of evofosfamide or ifosfamide in combination with docetaxel.