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Evofosfamide, but not ifosfamide, exhibits controlled oxygen concentration breathing condition-dependent antitumor activity in the ectopic H460 xenograft model. A and C, antitumor activity; B and D, body weight change as a readout of toxicity. Data are expressed as Mean ± SEM of 10 animals per group. Evo, evofosfamide; Ifo, ifosfamide; Doc, docetaxel. (A and C are from Reference 12).
