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At an equivalent hematoxicity level, antitumor activity of evofosfamide and ifosfamide in the H460 ectopic xenograft models. Evo, was given at 50 mg/kg, ip, and Ifo was given at 30 mg/kg ip at a regimen of QDx5/wk × 2 wks; A, antitumor activity as monotherapy. B, sunitinib was given at 80 mg/kg, QDx19, oral. Evo or Ifo was given 7 d after the initiation of sunitinib treatment. Data are expressed as Mean ± SEM of 10 animals per group.
