Table 1. Baseline characteristics in training cohort and validation cohort.
| Training cohort (n = 105) | Validation cohort (n = 209) | |||||
|---|---|---|---|---|---|---|
| MN (n = 41) | non-MN (n = 64) | P value | MN (n = 77) | non-MN (n = 132) | P value | |
| Age (yr.) | 64 (52, 69) | 54 (39, 65.5) | 0.015* | 67 (61, 71) | 63 (47, 71) | 0.010* |
| Male | 25 (60%) | 29 (45.3%) | 0.12 | 53 (68.8%) | 97 (73.5%) | 0.47 |
| History of DM | 3 (7.3%) | 15 (23.4%) | 0.032* | 11 (14.3%) | 36 (27.3%) | 0.030* |
| BMI (kg/m2) | 22.0 (19.5, 25.9) | 23.0 (20.8, 26.2) | 0.094 | 23.3 (21.5, 25.5) | 23.0 (21, 25.9) | 0.56 |
| SBP (mmHg) | 131 (121, 153) | 136.5 (122, 151) | 0.47 | 135 (125, 153) | 140 (125, 154) | 0.44 |
| UPCR (g/gCr) | 3.59 (2.49, 6.47) | 4.78 (1.42, 7.10) | 0.69 | 5.58 (3.39, 9.06) | 5.74 (4.04, 9.44) | 0.62 |
| UACR (g/gCr) | 2.59 (1.49, 4.61) | 2.89 (0.75, 5.14) | 0.71 | 3.74 (2.10, 5.18) | 3.59 (2.23, 5.31) | 0.95 |
| Microscopic hematuria | 16 (39%) | 29 (45.3%) | 0.53 | 40 (52.0%) | 74 (56.1%) | 0.57 |
| TP (g/dL) | 5.3 (4.6, 5.6) | 5.4 (4.7, 6.1) | 0.47 | 5.1 (4.6, 5.4) | 5.1 (4.6, 5.7) | 0.31 |
| Alb (g/dL) | 2.3 (1.9, 2.9) | 2.6 (1.8, 3.1) | 0.37 | 2.2 (1.8, 2.4) | 2.1 (1.7, 2.6) | 0.74 |
| TC (mg/dL) | 266 (227, 318) | 260 (196, 336) | 0.39 | 304 (253, 367) | 278 (201, 390) | 0.098 |
| Cr (mg/dL) | 0.8 (0.62, 1.05) | 1.01 (0.73, 1.45) | 0.025* | 0.83 (0.7, 1.05) | 1.06 (0.79, 1.61) | <0.001* |
| eGFR (ml/min/1.73m2) | 70.3 (49.9, 82.2) | 54.1 (35.2, 80.1) | 0.061 | 68.8 (53, 82.2) | 52.9 (32.5, 75.2) | <0.001* |
| ANA positive | 16 (40%) | 21 (32.8%) | 0.46 | 37 (48.1%) | 46 (34.9%) | 0.060 |
| u-PCX (μg/g) | 254.3 (148.4, 501.6) | 63.2 (39.7, 200.7) | <0.001* | 365.5 (208, 687) | 104.8 (34.4, 267.2) | <0.001* |
| u-AMG (mg/g) | 21.2 (13.9, 42.4) | 29.3 (12.0, 49.9) | 0.93 | 27 (20.1, 44.4) | 35.6 (20.4, 62.7) | 0.54 |
| u-BMG (μg/g) | 258.8 (123.3, 1915.2) | 224.5 (50.4, 3016.1) | 0.38 | 410.5 (170.5, 1565.7) | 572.3 (121.3, 6000.1) | 0.070 |
| u-NAG (IU/g) | 15.7 (8.84, 32.9) | 20.0 (7.71, 36.8) | 0.78 | 25.0 (16.4, 36.9) | 27.0 (15.6, 38.7) | 0.73 |
MN = membranous nephropathy; BMI = body mass index; SBP = systolic blood pressure; UPCR = urinary protein-to-creatinine ratio; UACR = urinary albumin-to-creatinine ratio; TP = total protein; Alb = albumin; TC = total cholesterol; Cr = creatinine; eGFR = estimated glomerular filtration rate; ANA = antinuclear antibody; u-PCX = urinary podocalyxin; u-AMG = urinary α1 microglobulin; u-BMG = urinary β2 microglobulin; u-NAG = urinary N-acetyl-β-D-glucosaminidase. Continuous data represent medians (1st quartile, 3rd quartile). Categorical data indicate n values (%).
* P value < 0.05