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. 2016 Sep 26;11(9):e0163768. doi: 10.1371/journal.pone.0163768

Fig 4. Role of PFK15 in cell apoptosis.

Fig 4

(a) MKN45 and AGS cells were treated with various concentrations of PFK15 and collected after 24 h. Then cells were analyzed by flow cytometry after stained with Annexin V and PI. The percentages of early apoptotic (Annexin V+/ PI-) and late apoptotic (Annexin V+/ PI+) cells were quantified. (b) PFK15 treatment significantly increased the percentage of apoptotic cells, indicating a time dependent effect on tested cells up to 48 h post-treatment. Data were analyzed by means ± SD and were representative of three independent experiments. *P<0.05, compared with controls.