ISDR case R02-170 cartilage growth plate histology. (A) Cartilage growth plate (10X)
showing poor hypertrophic column formation (arrow) with fibrous septae between the
columns; B, bone, H, hypertrophic zone, P, proliferative zone. (B) Proliferative zone
(10X) showing increased vascularity (arrows), decreased extracellular matrix and
hypercellularity. (C) Reserve chondrocytes (40X) with arrows identifying chondrocytes with
central round nuclei. (D) Cartilage stained with Goldner’s reagent showing a
fibrous band at the distal end of the growth plate (arrow) and thickened trabeculae in the
primary zone of ossification.