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. 2016 Sep 26;5:e17464. doi: 10.7554/eLife.17464

Figure 1. Memantine (MEM) treatment enhanced forgetting of contextual fear memory through the increase in adult hippocampal neurogenesis.

Figure 1.

(A) MEM treatment enhanced forgetting of contextual fear memory in a manner dependent on the number of MEM treatments. [VEH = vehicle-treated group, n = 10; MEM (1), n = 10; MEM (4), n = 10]. (B) MEM treatment enhanced forgetting of contextual fear memory in a dose-dependent manner (VEH group, n = 12; MEM25 group, n = 14; MEM50 group, n = 13). (C) Representative immunohistochemically stained BrdU-positive cells (red) and NeuN-positive cells (green) at 24 hr after Test 2. Scale bar = 100 µm. (D) The number of BrdU-positive cells in the dentate gyrus (DG) (VEH, n = 3; MEM25, n = 14; MEM50, n = 3). (E) Correlation between the number of BrdU-positive cells and the differences of freezing scores before and after the MEM treatments (MEM25 = 25 mg/kg body weight; MEM50 = 50 mg/kg body weight) in contextual fear conditioning tasks (n = 14). i.p. = intraperitoneal injection. *p<0.05. The results of the statistical analyses are presented in Figure 1—source data 1.

DOI: http://dx.doi.org/10.7554/eLife.17464.002

Figure 1—source data 1. Summary of statistical analyses with F values.
The asterisks indicate a significant difference.
DOI: http://dx.doi.org/10.7554/eLife.17464.003
elife-17464-fig1-data1.xlsx (9.2KB, xlsx)
DOI: 10.7554/eLife.17464.003
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