TABLE 1.

Pregnancy characteristics, offspring body weight and offspring inflammatory markers

Variable	N	H	HA	NA
Days of gestation	22.0 ± 0.1	22.1 ± 0.1	22.2 ± 0.1	22.0 ± 0.1
Litter size	13.4 ± 0.5	13.5 ± 0.5	12.5 ± 0.6	14.2 ± 0.5
Male:female ratio	0.9 ± 0.2	0.9 ± 0.2	1.0 ± 0.2	1.2 ± 0.2
Birth weight (g)	6.4 ± 0.3	6.4 ± 0.2	6.7 ± 0.1	6.3 ± 0.1
Weight (g)
4 mo	568.3 ± 13.6	552.3 ± 12.5	556.2 ± 11.5	548.2 ± 11.1
15 mo	810.2 ± 21.3	767.1 ± 29.1	785.9 ± 26.4	801.4 ± 27.2
Inflammatory markers
IFN γ (pg/ml)
4 mo	11.09 ± 1.2	9.6 ± 0.8	9.2 ± 1.5	11.6 ± 0.7
15 mo	11.2 ± 1.2	12.0 ± 1.4	12.0 ± 1.7	12.0 ± 1.4
IL-5 (pg/ml)
4 mo	88.0 ± 4.5	82.5 ± 3.3	78.3 ± 5.3	96.4 ± 4.7
15 mo	62.8 ± 6.6	63.2 ± 7.9	62.5 ± 5.4	73.9 ± 6.3
CRP (mg/L)
4 mo	255.3 ± 16.4	243.6 ± 11.1	266.9 ± 12.3	235.9 ± 11.5
15 mo	279.4 ± 20.7	257.3 ± 14.2	279.2 ± 16.6	269.9 ± 11.2

Values are means ± sem for the duration of pregnancy (days of gestation), litter size, male: female pup sex ratio, birth weight and body weight at 4 and 15 mo, as well as plasma concentration of the inflammatory markers at 4 and 15 mo. Groups are normoxic or hypoxic pregnancy with (NA, n = 22; HA, n = 25) or without (N, n = 20; hypoxic H, n = 23) maternal treatment with allopurinol. Inflammatory markers were obtained in a subset of offspring of n = 6 in each group. CRP, C reactive protein ; H, hypoxic; HA, hypoxic allopurinol; N, normoxic; NA, normoxic allopurinol.