Table 2.

Changes in patient-reported outcomes after liver transplant

	All patients (n=66)		Cognitive Impairment (n=42)		Cognitively unimpaired (n=24)
	Pre	Post	Pre	Post	Pre	Post
Beck Depression Inventory	14.7±9.4	10.0±8.8***	15.7±9.9	11.3±9.8**	12.8±8.2	8.2±6.8**
Total SIP	25.2±15.4	17.9±17.3*	29.7±15.3††	21.5±19.4**	17.6±12.3	12.6±12.4
Psychosocial SIP	22.4±18.5	15.4±20.7*	26.1±19.3†	19.1±24.8	16.0±15.4	10.0±11.2
Physical SIP	20.8±16.8	14.1±17.2*	26.0±16.6††	18.1±18.6*†	12.1±13.6	8.3±13.3
PROMIS tools
Anger	49.7±29.4	41.9±29.8	48.7±31.1	44.0±32.7	51.0±27.8	38.9±25.8*
Anxiety	64.7±24.1	56.4±26.2**	67.4±23.7	59.4±27.0*	61.2±24.8	52.3±25.3
Depression	52.6±24.5	44.5±26.4*	54.0±25.6	46.4±29.0	50.8±23.5	41.7±22.8*
Fatigue	66.9±24.6	52.1±27.4**	64.4±28.1	51.9±28.1*	70.4±19.2	52.5±27.2**
Physical function‡	22.1±19.0	34.3±21.7**	21.4±18.5	31.5±19.9*	23.0±20.0	38.3±24.0**
Pain-related behavior	61.5±27.4	51.1±28.7*	68.3±23.3†	54.0±29.0*	52.3±30.3	47.1±28.6
Pain-related interference	62.8±35.0	51.3±31.5*	70.9±32.7	53.6±31.7*	51.8±35.9	48.1±31.8
Social impairment‡	30.9±23.7	38.5±27.3*	25.9±21.3	35.5±26.9	37.6±25.5	42.8±28.1
Social role‡	19.0±16.8	45.7±26.2***	18.1±17.4	41.1±25.4***	20.3±16.3	52.1±26.6***
Sleep disturbance	70.7±27.2	54.7±30.2**	70.9±27.7	54.2±29.9*	70.4±27.1	55.4±31.6*
Sleep-related impairment	72.3±25.0	55.0±30.9***	74.5±26.2	56.5±31.4**	69.4±23.6	52.9±31.0**

All data presented as mean±SD.

^*p<0.05

^**p<0.01

^***p<0.001 pre vs. post-transplant

^†p<0.05

^††p<0.01

†††:p<0.001 Cognitively impaired vs. Cognitively unimpaired groups.

^‡Low score in these PROMIS tools indicates poor function compared to US-norms; a higher score indicates poor function in other domains.

PROMIS: Patient-reported outcomes measurement information system, SIP: sickness impact profile.