Table 4.

Waning effects of a single course of antenatal betamethasone on neonatal morbidly

Neonatal Morbidity	Unadjusted Odds ratio (or Coefficient) for Time to delivery ≥ 10 days (95% CI)	Adjusted* Odds ratio (or Coefficient) for Time to delivery ≥ 10 days (95% CI)	P value†
Severe IVH‡ (%)	2.67 (1.26–5.61)	4.16 (1.59–10.87)	0.004
Intubated-Mechanical Ventilation at 24h (%)	1.05 (0.58–1.89)	3.23(1.59–6.57)	0.001
Respiratory Severity Score at 24h (mean ± SD)§	0.19 (CI −0.22, 0.59)	0.39 (CI 0.10–0.84)	0.029
Death (%)	0.40 (0.09–1.80)	1.37 (0.58–3.20)	0.468
BPD** or death (%)	1.50 (0.64–3.60)	1.26(0.68–2.4)	0.460
NEC†† or death (%)	1.00 (0.39–2.60)	1.30 (0.65–2.6)	0.468

Note: all infants completed a two dose course of antenatal betamethasone

^*Adjusted for gestational age at birth, small for gestational age, preeclampsia, multiple birth, gestational diabetes and birth year epoch.

^†P value for adjusted odds ratio or coefficient

^‡Grade 3 or 4

^§Respiratory Severity Score (RSS) = mean airway pressure x fraction of inspired oxygen. By convention, mean airway pressure = liter flow rate when infants received nasal cannula flows of ≤3 liter/min; measurements made at 24 hours after birth; linear regression with bootstrapping coefficient and bias corrected confidence interval reported

^**Bronchopulmonary Dysplasia (BPD), physiologic definition by room air challenge at 36 weeks post menstrual age

^††Necrotizing enterocolitis, Bell’s classification ≥II (treated medically or surgically) and “spontaneous perforations”