Table 2.
Echocardiography Measures [Median (Min-Max) or Mean (SD)] by Treatment Group and Gender
| Outcome | Female | Male | ||||
|---|---|---|---|---|---|---|
| M | M+R | M+L | M | M+R | M+L | |
| LV mass (g) * | 134 (76–205) | 129 (74–204) | 117 (79–182) | 178 (102–269) | 166 (91–314) | 158 (105–364) |
| LV mass/height2.7 (g/m2.7) * | 34.5 (22.3–49.8) | 33.5 (19.1–52.8) | 32.4 (18.1–50.2) | 39.4 (27.7–60.8) | 37.7 (23.2–57.4) | 36.1 (24.8–73.8) |
| LV relative wall thickness | 0.31 (0.24–0.50) | 0.32 (0.22–0.58) | 0.31 (0.25–0.54) | 0.34 (0.27–0.56) | 0.32 (0.25–0.45) | 0.33 (0.25–0.60) |
| LV fractional shortening (%) | 38.9 (4.7) | 36.6 (4.7) | 39.5 (5.0) | 40.2 (6.2) | 37.2 (4.4) | 36.60 (5.8) |
| LA internal dimension (cm) * | 3.5 (0.4) | 3.6 (0.5) | 3.37 (0.46) | 3.6 (0.40) | 3.7 (0.4) | 3.6 (0.5) |
| LA internal dimension/height (cm/m) | 2.1 (0.2) | 2.2 (0.3) | 2.1 (0.3) | 2.1 (0.2) | 2.1 (0.2) | 2.1 (0.3) |
| TAPSE (cm) | 2.1 (0.3) | 2.2 (0.4) | 2.1 (0.4) | 2.1 (0.4) | 2.2 (0.3) | 2.1 (0.4) |
| Doppler diastology | ||||||
| LV E (cm/sec) * | 96.8 (20.6) | 90.6 (14.9) | 99.3 (20.6) | 88.8 (19.1) | 87.9 (18.0) | 89.5 (14.7) |
| LV Em (cm/sec) | 16.6 (4.1) | 17.7 (4.1) | 16.3 (3.7) | 16.6 (5.0) | 17.1 (4.5) | 17.39 (6.5) |
| E/Em ratio | 6.2 (1.9) | 5.4 (1.4) | 6.4 (1.8) | 5.8 (1.8) | 5.3 (1.2) | 5.8 (2.4) |
Abbreviations: M = metformin only; M+R = metformin + rosiglitazone; M+L = metformin + lifestyle program; LV = left ventricular; LA = left atrial; TAPSE = tricuspid annular plane systolic excursion
*
Females significantly different from males, p<.05.